log P_v: Calculate marginal probability of observed genotypes under variant-level pathogenicity model
Description
Calculate marginal probability of observed genotypes under variant-level pathogenicity model
Usage
"log P_v"(y, G, min_ac = 1, ...)
Arguments
y
Logical vector of case (TRUE) control (FALSE) status.
G
Integer matrix of variant counts per individual, one column per individual and one row per variant.
min_ac
Minimum allele count per individual to be considered to have a pathogenic combination of variants. '1' could correspond to a dominant inheritance hypothesis whereas '2' could correspond to a recessive inheritance hypothesis.